The genetic disorder is due to the mutation of a single nucleotide, from a GAG to GTG codon on the coding strand. In people heterozygous for HgbS (carriers of sickling haemoglobin), the polymerisation problems are minor, because the normal allele is able to produce over 5% of the haemoglobin. In people homozygous for HgbS, the presence of longchain polymers of HbS distort the shape of the red blood cell from a smooth doughnutlike shape to ragged and full of spikes, making it fragile and susceptible to breaking within capillaries
Sample Type - Blood
Reporting Time - Please Call Customer care
Prerequisites - No special preparation required
Price - ₹4550/-
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